Iziko has three business units, namely Core Functions; Operations; and the Office of the CEO, comprising the departments of Advancement, and Finance and Administration.

• The Core Functions unit includes the departments of Collections and Digitisation; Research and Exhibitions; and Education;
• The Operations unit includes the departments of Support Services and Human Resources;
• The heads of the Core Functions and Operations departments – along with the Chief Financial Officer, the Director Advancement and the members of the Corporate Governance and Compliance Committee – constitute the Senior Management Team (SMT) of Iziko, under the leadership of the CEO.